Absolutely, and worthwhile doing, as long as in the final analysis you trust what your ears are telling you, not just the measurements!
Again I have to state quite categorically that, in my set up, there is no hint whatsoever of the Tissie sounding 'etched', sharp or harsh - simply very transparent of the signal that it's being fed.
However, I could imagine that due to its brutal honesty, in some set-ups, especially those with a tendency towards forwardness [and where various 'sticking plasters' have been applied to address it], such wide-open transparency may become a bit 'too much of a good thing'.
Marco.