Location: London/Durham
Posts: 6,878
I'm Lawrence.
There could be advantages, but to make a fair comparison you should compare like with like, including on a cost basis.
So if you have a biwire cable, compare it connected as biwire, to both cables connected in parallel to both terminals, that way you don't have a guage advantage to skew the results. (You can also try a single run too just in case it works better, which it can.)
And if you want to compare bi wire to a single wire cable then they should cost the same, meaning the single wire will be much better quality being twice the price per metre.