Adrian and Marco
Some good points - for example long term sleep deprivation not good - usually correlates with poor health and reduced life expectancy. Retiring - yes - can be a good option, but a lot depends on how viable it is. Relocating/downsizing - we can't talk. We relocated, but actually our new house is bigger than our previous one. This has enormous advantages in that we can store more of the things we have - so big speakers and musical instruments should be less of a problem - but getting that kind of advantage is I think unusual.
Relocating can be very stressful in itself, and doesn't necessarily bring benefits. Downsizing/relocating may bring financial benefits - but these need to be considered carefully. If you like the area you live in, and have friends and family there, and downsizing would be feasible and release capital, then think about that.
Weather also may be a significant factor - though affects people differently. I probably wouldn't advise anyone living in the very south of England to move to the far north of the UK without considering how the weather would affect them. What may be now extreme heat and sun could be swapped for a lot less sun and a significantly colder experience. The mid band - round where Marco lives is probably a fairly sweet spot.
The most capital release is probably going to be for people in and around London, moving to another more distant area. Sometimes it can work - but for other people it may not be a good move. Besides friends and family, there are other factors - health care in the area - do you get on with your GP and are the hospitals good?
If current work is difficult is there other work which can be done - for example using on-line working, which might now be more acceptable than it was a year ago? If someone has specific skills, then there are opportunities to generate income that way - and I don't mean by the sort of get rich quick adverts you see both on-line and in low end newspapers.
If work with the current employer is difficult, maybe try to negotiate a phased exit, rather that just go for a complete break. The employer might be happier with that, but would have to accept that you could take on other outside work. Note also that my observations from other people suggest that taking on "half time" work, for 50% of the pay isn't always a good deal, as often people on reduced hours working actually do proportionately more work, but get less reward. Also note that if one's agreed working hours are reduced below a certain level, then contracts and responsibilities can change quite a bit - not necessarily in an employee's favour. More unscrupulous empoyers will exploit that.
Mobility is another issue - if you moved. Would you be able to travel on public transport - would you still be able to drive? Driving in more remote parts of the UK is easier, but distances are further.
So yes - think carefully about how to proceed, but don't go jumping from one not very good situation into one which could be worse. Downsizing and relocating have to be thought out really rather carefully, as for many people there's no coming back.
Good luck with it all.