By rights the Caiman driving a power amp ought to offer the cleaner sound because there are less components in the analogue chain, but the precise input/output impedance characteristics can sometimes mean the sound is better with a pre-amp.
I can only share my experience with the Beresford 7510. I have not repeated the experiment with the Caiman, which is reputed to have a better analogue output section.
Cleanest option:
Squeezebox > Standac (fixed out)> Quad 405-2 > Speakers
Relies on 24 bit digital remote volume control in Squeezbox.
Input/output sensitivity need to be matched so as to run at about 90% volume or else the digital volume control may degrade the sound. If the Standac had overdriven the power amp I could have inserted high quality in-line attenuators to the same effect.
I do not use this option because I also need a feed from a Virgin Cable TV box, which has no volume control. You would need to be very sure of your hardware and software to omit an analogue volume control - one digital crack could blow your tweeters.
My Chosen option:
Squeezebox and Virgin Box > Standac (variable out) > Quad 405-2 > Speakers
Very marginally less clarity on my most revealing recordings. Caiman may have closed the gap. Uses manual volume control on Standac about which my daughter complains bitterly when she is watching TV!
Least clear option.
Ssqueezebox and Virgin Box > Standac (fixed output) > Quad 77 Integrated Amp > Speakers
This option gives a remote analogue volume control and the ability to play analogue sources, but lacks the clarity and drive of the other options. The power amplifier in the Quad 77 Integrated amp is quite a few years younger than the 405-2, but that has been very recently upgraded and has all new capacitors and central op-amp. The 405-2 is the better, more powerful, amp and that shows. The 77 Integrated is renowned for a smooth laid back presentation, and that it delivers, but the power amp lacks the clout of the 405, and the pre-amp introduces its losses.
I have once driven the 405-2 from the Pre-out on the 77 integrated amp. The sheer power 405-2 shows, but so does the marginal clouding of the pre-amp.
Conclusion
All these options achieve very acceptable standards and I will happily listen to any. They trade clarity against convenience. You can only make your own judgements.

