Science needs you!
Please enroll for this simple 10 minute test to demonstrate that it's actually possible:
http://www.trustmeimascientist.com/2...ist-challenge/
They've made it really easy for you as you'll 'only' be spotting the difference between a 320kbs Mp3 and a 16bit 44.1 wav (or higher resolution) which for anyone capable of hearing the difference between wav and aiff (for instance) should be a freaking doddle. They'll help out by supplying the files (of music of your choosing) you can use your own prefered system and you can practice as much as you like. You can use Foobar's ABX tool or there's a neat open source tool here: http://abx-comparator.berlios.de/
Now is the chance to put all those terrible, cynical neighsayers in their place and prove once and for all that it really does matter and that it's clearly audible.
There's a nice follow up piece here: http://www.trustmeimascientist.com/2...mount-everest/ which you'll also have the opportunity to prove wrong.
NB: I appreciate that they've used an 'offensive' term in the title of their article but I beg that you don't let it distract you from the chance to settle this debate once and for all and prove that there is a difference that you can repeatably hear.
I'm not sure that I will hear a difference but in the spirit of investigation I'm going to take the test and see how I do, I urge you to also. The greater the body of research the better the quality of the claims it's able to make.