My computer stuff is ancient now (mid noughties), but the 7 port externally powered USB hub did sometimes seem to clog up when transferring files from one to other drive(s) connected to it. I've been lent a 2TB drive for my extended listening pleasure, but I've only used it into one of the main USB ports with no playback issues at all..
Call me ancient and old fashioned (I know, I know..), but it does seem to make sense to have an audio server set up as simply as possible, with as little hanging off it as possible - IMO at present...
Tear down these walls; Cut the ties that held me
Crying out at the top of my voice; Tell me now if you can hear me